International Association of Animal Therapists
Case Study

20/02/2018

Improving Kidney Failure with Stem Cell Therapy

A positive side effect of Stem Cell Therapy could bring a clinical solution for your cat.
Until now, chronic renal failure cannot be reversed, and in most cases, will progress over time despite appropriate therapy. New therapeutic approaches have been able to reduce protein urea , but can only slow down disease progression, as regenerative tissue repair is the only way to stop disease progression. Thus, cell therapies associated with regenerative effects are attracting increasing interest. A safe minimally invasive regenerative therapy for CKD in cats could dramatically improve the quality and length of life for the veterinary patient.
In regenerative medicine bioactive cells are used to repair damaged or non-functioning tissues or organs. Mesenchymal stem cells (MSCs) are adult multipotent non-hematopoietic cells. In addition MSC are able to transdifferentiate (other cell lineages), including renal cells (such as tubular and endothelial cells). MSC also exert trophic, immunosuppressive, anti-inflammatory and anti-apoptotic effects through direct (cell-cell) and indirect (growth factors) interactions and activate the body’s own stem/progenitor cells, modulating the local environment and thereby stimulating local tissue repair .
Adipose-derived stem cells (ASC) are the most highly characterized and are considered comparable in morphology, immune phenotype and differentiation capacity. ASC retain their characteristics with long-term passaging. Both have demonstrated broad multi potency and immunosuppressive effects. It is this effect and improvement that can be seen in the medulla of the kidney as a positive result.

Case Study in Point:
Cat: male, 5 years old
History: No underlying liver, bone, intestinal, or parathyroïd disease.
Symptoms: Lethargy, vomiting, weight loss, dehydratation, neurological deficits (stiffness, crooked head)
Diagnosis: Chronic renal failure IRIS stage 4
Therapy: Mesenchymal stem cell therapy at 30/05/2013 intra-renal injection. Extra: renal diet, ipakitine and fortekor. Started in veterinary clinic and proceeded after 3 days (clinical improvement) at home.
Results: Three months after treatment values of creatinine and ureum in the blood were diminished untill almost normal levels. From the creatinine values we can conclude that the cat went from severe renal failure status to a pre-renal failure status (IRIS stage 1-2). Ureum values show, in accordance with creatinine, a good improvement in kidney function (more functional nephrons). Glomelar filtration rate was not measured but is estimated to have increased from 15% tot 45%. Phosphate decreased which is is positive as excess phosphate is detrimental for the kidneys.
Conclusion: The cat significantly improved in kidney function. Physical activity, neurological status and general wellbeing of the cat improved after therapy. No more digestion or hydration problems have occured. 6 months later the cat is still doing really well.
 

 

Case study received with thanks, from Fat-Stem Laboratories (www.fat-stem.com)

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